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University of Surrey, Faculty of Health and Medical SciencesMolecular Medicine Group, John McVey
 

Publications


Peer Reviewed Journals
  1. Wilkinson, H., Leonard, H., Chen, D., Lawrence, T., Robson, M., Goossens, P., McVey, J. H., Dorling, A. (2021). PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses. iScience 23101981.
    [ ABSTRACT ] [ FULL TEXT ]
  2. Chen, D., Li, K., Festenstein, S., Karegli, J., Wilkinson, H., Leonard, H., Wei, L.-L., Ma, N., Xia, M., Tam, H., Wang, J.-a., Xu, Q., McVey, J. H., Smith, R. A. G., Dorling, A. (2020). Regression of atherosclerosis in ApoE-/- mice via modulation of monocyte recruitment and phenotype, induced by weekly dosing of a novel "cytotopic" anti-thrombin without prolonged anticoagulation. Journal of the Heart Association 9. e014811..
    [ ABSTRACT ] [ FULL TEXT ]
  3. Chowdary, P., Hamid, C., Slatter, D., Morris, R., Foley, J. H., Gomez, K., Brodkin, E., Fox, T. A., Gatt, A., McVey, J. H. (2020). Impaired platelet-dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro. Research and Practice in Thrombosis and Haemostasis 14, 334-342.
    [ ABSTRACT ] [ FULL TEXT ]
  4. Giansily-Blaizot, M., Rallapalli, P. M., Perkins, S. J., Kemball-Cook, G., Hampshire, D. J., Gomez, K., Ludlam, C. A., McVey, J. H. (2020). The EAHAD Blood Coagulation Factor VII Variant Database. Human Mutation 41, 1209-1219.
    [ ABSTRACT ] [ FULL TEXT ]
  5. McVey, J. H., Rallapalli, P. M., Kemball-Cook, G., Hampshire, D. J., Giansily-Blaizot, M., Gomez, K., Perkins, S. J., Ludlamm C. A. (2020). The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers. Haemophilia 26, 306-314.
    [ ABSTRACT ] [ FULL TEXT ]
  6. Chen, D., Li ,K,. Tham, E.-L., Wei, L.-L., Ma, N., Dodd, P. C., Luo, Y., Kirchhofer, D., McVey, J. H., Dorling, A. (2018). Inhibition of angiopoietin-2 production by myofibrocytes inhibits neointimal hyperplasia after endoluminal injury in mice. Frontiers in Immunology 9, 1517.
    [ ABSTRACT ] [ FULL TEXT ]
  7. Donadon, I., McVey, J. H., Garagiola, I. , Branchini, A., Mortarino, M., Peyvandi, F., Bernardi, F., Pinotti, M. (2018). Clustered F8 missense mutations cause hemophilia A by combined alteration of splicing and protein biosynthesis/activity. Haematologica 103, 344-350.
    [ ABSTRACT ] [ FULL TEXT ]
  8. Maamoun, H., Zachariah, M., McVey, J. H., Green, F. R., Agouni, A. (2017). Heme oxygenase (HO)-1 induction prevents endoplasmic reticulum stress-mediated endothelial cell death and impaired angiogenic capacity. Biochemical Pharmacology 127, 46-59.
    [ ABSTRACT ]
  9. Shestopal, S. A., Hao, J.-J., Karnaukhova, E., Liang, Y., Ovanesov, M. V., Lin, M., Kurasawa, J. H., Lee, T. K., McVey, J. H., Sarafanov, A. G. (2017). Expression and characterization of a codon-optimized blood coagulation factor VIII. Journal of Thrombosis and Haemostasis 15, 709-720.
    [ ABSTRACT ]
  10. McVey, J. H. (2016). The role of the tissue factor pathway in haemostasis and beyond. Current Opinion in Hematology 23, 453-461.
    [ ABSTRACT ]
  11. Ma, J., Duffy, M. R., Deng, L., Dakin, R. S., Uil, T., Custers, J., Kelly, S. M., McVey, J. H., Nicklin, S. A., Baker, A. H. (2015). Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo. PLoS Pathogens 11, e1004673.
    [ ABSTRACT ] [ FULL TEXT ]
  12. Di Matteo, M., Samara-Kuko, E., Ward, N. J., Waddingon, S. N., McVey, J. H., Chuah, M. K. L., VandenDriessche, T. (2014). Hyperactive PIGGYBAC transposons for sustained and robust liver-targeted gene therapy. Molecular Therapy 22, 1614-1624.
    [ ABSTRACT ] [ FULL TEXT ]
  13. Chen, D., Ma, L., Tham, E.-L., Maresh, S., Lechler, R. I., McVey, J. H., Dorling, A. (2013). Fibrocytes mediate intimal hyperplasia post-vascular injury and are regulated by two tissue factor-dependent mechanisms. Journal of Thrombosis and Haemostasis 11, 963-974.
    [ ABSTRACT ]
  14. Chen, D., McVey, J. H., Dorling, A. (2013). Enhanced effect of inhibition of thrombin on endothelium in murine endotoxaemia: Specific inhibition of thrombocytopenia. Thrombosis Research 132, 750-756.
    [ ABSTRACT ]
  15. McIntosh, J., Lenting, P. J., Rosales, C., Lee, D., Rabbanian, S., Raj, D., Patel, N., Tuddenham, E. G. D., Christophe, O. D., McVey, J. H., Waddington, S., Nienhuis, A. W., Gray, J. T., Fagone, P., Mingozzi, F., Zhou, S.-Z., High, K. A., Cancio, M., Ng, C. Y. C., Zhou, J., Morton, C. L., Davidoff, A. M., Nathwani, A. C. (2013). Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant. Blood 25, 3335-3344.
    [ ABSTRACT ]
  16. Shrivastava, S., Ma, L., Tham, E.-L., McVey, J. H., Chen, D., Dorling, A. (2013). Protease activated receptor-2 signalling by tissue factor on dendritic cells suppresses antigen-specific CD4+ T cell priming. Immunology 139, 219-226.
    [ ABSTRACT ]
  17. Binny, C., McIntosh, J., Della Peruta, M., Kymalainen, H., Tuddenham, E. G. D., Buckley, S. M. K., Waddington, S. N., McVey, J. H., Spence, Y., Morton, C. L., Thrasher, A. J., Gray, J. T., Castellino, F. J., Tarantal, A. F., Davidoff, A. M., Nathwani, A. C. (2012). AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood 119, 957-966.
    [ ABSTRACT ]
  18. Chen, D., Shrivastava, S., Ma, L., Tham, E.-L., Abrahams, J., Coe, J. D., Scott, D., Lechler, R. I., McVey, J. H., Dorling, A. (2012). Inhibition of thrombin receptor signaling on α-smooth muscle actin+ CD34+ progenitors leads to repair after murine immune vascular injury. Arteriosclerosis, Thrombosis, and Vascular Biology 32, 42-49.
    [ ABSTRACT ] [ FULL TEXT ]
  19. McVey, J. H. (2012). Factor seven-activating protease: does it do what it says on the tin? Journal of Thrombosis and Haemostasis 10, 857-858.
  20. Rahim, A. A., Wong, A. M., Ahmadi, S., Hoefer, K., Buckley, S. M. K., Hughes, D. A., Nathwani, A. N., Baker, A. H., McVey, J. H., Cooper, J. D., Waddington, S. N. (2012). In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression. Gene Therapy 19, 936-946.
    [ ABSTRACT ] [ FULL TEXT ]
  21. Duffy, M. R., Bradshaw, A. C., Parker, A. L., McVey, J. H., Baker, A. H. (2011). A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes. Journal of Virology 20, 100914-100919.
    [ ABSTRACT ]
  22. Goodeve, A. C., Reitsma, P., McVey, J. H., on behalf of the Working Group on Nomenclature of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis (2011). Scientific and standardisation committee communication: a standard system for nomenclature of genetic variants in haemostasis. Journal of Thrombosis and Haemostasis 9, 852-855.
    [ FULL TEXT ]
  23. Ward, N. J., Buckley, S. M. K., Waddington, S. N., VandenDriessche, T., Chuah, M. K. L., Nathwani, A. C., McIntosh, J., Tuddenham, E. G. D., Kinnon, C., Thrasher, A. J., McVey, J. H. (2011). Codon optimisation of human factor VIII cDNAs leads to high level expression. Blood 117, 798-807.
    [ ABSTRACT ] [ SUPPLEMENTAL FIGURE ]
  24. Alba, R., Bradshaw, A. C., Coughlan, L., Denby, L., McDonald, R. A., Waddington, S. N., Buckley, S. M. K., Greig, J. A., Parker, A. L., Miller, A. M., Wang, H., Lieber, A., van Rooijen, N., McVey, J. H., Nicklin, S. A., Baker, A. H. (2010). Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood 116, 2656-2654.
    [ ABSTRACT ]
  25. McVey, J. H. (2010). O tissue factor, where art thou tissue factor. Blood 116, 676-677.
    [ FULL TEXT ]
  26. Alba, R., Bradshaw, A. C., Parker, A. L., Bhella, D., Waddington, S. N., Nicklin, S. A., van Rooijen, N., Custers, J., Goudsmit, J., Barouch, D. H., McVey, J. H., Baker, A. H. (2009). Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood 114, 965-971.
    [ ABSTRACT ] [ EDITORIAL COMMENT ]
  27. Greig, J. A., Buckley, S. M. K., Waddington, S. N., Parker, A. L., Bhella, D., Pink, R., Rahim, A. A., Morita, T., Nicklin, S. A., McVey, J. H., Baker, A. H. (2009). Influence of coagulation factor X on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35 and chimeric Ad5/Ad35 vectors. Molecular Therapy 17, 1683-1691.
    [ COVER ] [ ABSTRACT ] [ FULL TEXT ]
  28. Lenaerts, L., McVey, J. H., Baker, A. H., Denby, L., Nicklin, S., Verbeken, E., Naesens, L. (2009). Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting. The Journal of Gene Medicine 11, 119-127.
    [ ABSTRACT ]
  29. Maroney, S. A., Ferrel, J. P., Pan, S., White, T. A., Simari, R. D., McVey, J. H., Mast, A. E. (2009). Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice. Journal of Thrombosis and Haemostasis 7, 1106-1113.
    [ ABSTRACT ]
  30. McVey, J. H. (2009). FVIIa gene delivery: potential treatment for hemophilia? Blood 113, 3649-3650.
    [ COVER ] [ FULL TEXT ]
  31. Parker, A. L., Waddington, S. N., Buckley, S. M. K., Custers, J., Havenga, M. J. E., van Rooijen, N., Goudsmit, J., McVey, J. H., Nicklin, S. A., Baker, A. H. (2009). Effect of neutralising sera on factor X-mediated adenoviral serotype 5 gene transfer.
    Journal of Virology 83, 479-483.
    [ ABSTRACT ] [ FULL TEXT ]
  32. Chen, D., Abrahams, J. M., Smith, L. M., McVey, J. H., Lechler, R. I., Dorling A. (2008). Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors. Blood 11, 4155-4164.
    [ ABSTRACT ] [ FULL TEXT ]
  33. Chen, D., Carpenter, A., Abrahams, J., Chambers, R. C., Lechler, R. I., McVey, J. H., Dorling, A. (2008). Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo. The Journal of Experimental Medicine 8, 1739-1746.
    [ ABSTRACT ] [ FULL TEXT ]
  34. Lin, C. C., Chen, D., McVey, J. H., Cooper, D. K. C., Dorling, A. (2008). Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells. Transplantation 86, 702-7009.
    [ ABSTRACT ]
  35. Waddington, S. N., McVey, J. H., Bhella, D., Parker, A. L., Barker, K., Atoda, H., Pink, R., Buckley, S. M. K., Greig, J. A., Denby, L., Custers, J., Morita, T., Francischetti, I. M. B., Monteiro, R. Q., Barouch, D. H., van Rooijen, N., Napoli, C., Havenga, M. J. E., Nicklin, S. A., Baker, A. H. (2008). Adenovirus serotype 5 hexon mediates liver gene transfer. Cell 132, 397-4009.
    [ ABSTRACT ]
  36. Wang, H., Liu, Y., Li, Z., Tuve, S., Stone, D., Kalyushniy, O., Shayakhmetov, D., Verlinde, C. L. M., Stehle, T., McVey, J., Baker, A., Peng, K.-W., Roffler, S., Lieber, A. (2008). In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46. Journal of Virology 82, 10567-10579.
    [ ABSTRACT ]
  37. White, K., Büning, H., Kritz, A., Janicki, H., McVey, J., Perabo, L., Murphy, G., Odenthal, M., Work, L. M., Hallek, M., Nicklin, S. A., Baker, A. H. (2008). Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions. Gene Therapy 15, 443-451.
    [ ABSTRACT ]
  38. Baker, A. H., Mcvey, J. H., Waddington, S. N., Di Paolo, N. C., Shayakhmetov, D. M. (2007). The influence of blood on in vivo adenovirus bio-distribution and transduction. Molecular Therapy 15, 1410-1416.
    [ ABSTRACT ]
  39. Bolton-Maggs, P. H. B., Hay, C. R. M., Shanks, D., Mitchell, M. J., McVey, J. H. (2007). The importance of tissue factor source in the management of Factor VII deficiency. Thrombosis and Haemostasis 97, 151-152.
  40. Denby, L., Work, L. M., Von Seggern, D. J., Wu, E., McVey, J. H., Nicklin, S. A., Baker, A. H. (2007). Development of renal-targeted vectors through combined in vivo phage display and caspid engineering of adenoviral fibers from serotype 19p. Molecular Therapy 15, 1647-1654.
    [ ABSTRACT ]
  41. Kritz, A. B., Nicol, C. G., Dishart, K. L., Nelson, R., Holbeck, S., Von Seggern, D. J., Work, L. M., McVey, J. H., Nicklin, S. A., Baker, A. H. (2007). Adenovirus 5 fibers mutated at the KKTK putative HSPG binding site fail to retarget when engineered with targeting peptides in the HI loop. Molecular Therapy 15, 741-749.
    [ ABSTRACT ]
  42. Parker, A. L., McVey, J. H., Doctor, J. H., Lopez-Franco, O., Waddington, S. N., Havenga, M. J. E., Nicklin, S. A., Baker, A. H. (2007). Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D. Journal of Virology 81, 3627-3631.
    [ ABSTRACT ]
  43. Shrivastava, S., McVey, J. H., Dorling, A. (2007). The interface between coagulation and immunity. American Journal of Transplantation 7, 499-506.
    [ ABSTRACT ]
  44. Waddington, S. N., Parker, A. L., Havenga, M., Nicklin, S. A., Buckley, S. M. K., McVey, J. H., Baker, A. H. (2007). Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: a fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5. Journal of Virology 81, 9568-9672.
    [ ABSTRACT ]
  45. Chen, D., Weber, M., Shiels, P. G., Dong, R., Webster, Z., McVey, J. H., Kemball-Cook, G., Tuddenham, E. G. D., Lechler, R. I., Dorling, A. (2006). Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progentor cells expressing membrane-tethered anticoagulant fusion proteins. Journal of Thrombosis and Haemostasis 4, 2191-2198.
    [ ABSTRACT ] [ FULL TEXT ]
  46. Gomez, K., McVey, J. H. (2006). Tissue factor initiated blood coagulation. Frontiers in Bioscience 11, 1349-1359.
    [ ABSTRACT ]
  47. Parker, A. L., Waddington, S. N., Nicol, C. G., Shayakhmetov, D. M., Buckley, S. M., Denby, L., Kemball-Cook, G., Ni, S., Lieber, A., McVey, J. H., Nicklin, S. A., Baker, A. H. (2006). Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes. Blood 108, 2554-2561.
    [ ABSTRACT ]
  48. Albrecht, C., McVey, J. H., Elliott, J. I., Sardini, A., Kasza, I., Mumford, A. D., Naoumova, R. P., Tuddenham, E. G., Szabo, K., Higgins, C. F. (2005). A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. Blood 106, 542-549.
    [ ABSTRACT ]
  49. Elliott, J. I., McVey, J. H., Higgins, C. F. (2005). The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products. Arthritis Research & Therapy 7, R468-R475.
    [ ABSTRACT ] [ FULL TEXT ]
  50. Gomez, K., McVey, J. H., Tuddenham, E. (2005). Inhibition of coagulation by macromolecular complexes. Haematologica 90, 1570-1576.
    [ ABSTRACT ]
  51. McVey, J. H., Lal, K., Imanaka, Y., Kemball-Cook, G., Bolton-Maggs, P. H. B., Tuddenham, E. G. D. (2005). Characterisation of blood coagulation factor XI T475I. Thrombosis and Haemostasis 93, 1082-1088.
    [ ABSTRACT ]
  52. Mumford, A. D., Chen, D., Dorling, A., Kemball-Cook, G., McVey, J. H. (2005). Generation of a polyclonal rabbit anti-mouse tissue factor antibody by nucleic acid immunisation. Thrombosis and Haemostasis 93, 160-164.
    [ ABSTRACT ]
  53. Chen, D., Giannopoulos, K., Shiels, P. G., Webster, Z., McVey, J. H., Kemball-Cook, G., Tuddenham, E., Moore, M., Lechler, R., Dorling, A. (2004). Inhibition of intravascular thrombosis in murine endotoxaemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. Blood 104, 1344-1349.
    [ ABSTRACT ] [ FULL TEXT ]
  54. Chen, D., Weber, M., McVey, J. H., Kemball-Cook, G., Tuddenham, E. G. D., Lechler, R. I., Dorling, A. (2004). Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. American Journal of Transplantation 4, 1958-1963.
    [ ABSTRACT ] [ FULL TEXT ]
  55. Elliott, J. I., Mumford, A. D., Albrecht, C., Collins, P. W., Giddings, J. C., Higgins, C. F., Tuddenham, E. G. D., McVey, J. H. (2004). Characterisation of lymphocyte responses to Ca2+ in Scott syndrome. Thrombosis and Haemostasis 91, 412-415.
  56. Gomez, K., Laffan, M. A., Kemball-Cook, G., Pasi, J., Layton, M., Singer, J. D., Tuddenham, E. G. D., McVey J. H. (2004). Two novel mutations in severe factor VII deficiency. British Journal of Haematology 126, 105-110.
    [ ABSTRACT ]
  57. Mumford, A. D., McVey, J. H. (2004). Tissue factors in the myocardium: Evidence of roles in haemostasis and inflammation. Disease Markers 20, 353-358.
    [ ABSTRACT ]
  58. Steen, M., Norstrøm, E. A., Tholander, A.-L., Bolton-Maggs, P. H. B., Mumford, A., McVey, J. H., Tuddenham, E. G., Dahlbäck, B. (2004). Functional characterization of Factor V-Ile359Thr: a novel mutation associated with thrombosis. Blood 103, 3381-3387.
    [ ABSTRACT ] [ FULL TEXT ]
  59. Takács, K., Du Roure, C., Nabarro, S., Dillon, N., McVey, J. H., Webster, Z., MacNeil, A., Bartók, I., Higgins, C., Gray, D., Merkenschlager, M., Fisher, A. G. (2004). The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 101, 16298-16303.
    [ ABSTRACT ]
  60. Bachli, E. B., Pech, C. M., Johnson, K. M., Johnson, D. J. D., Tuddenahm, E. G. D., McVey, J. H. (2003). Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts. Journal of Thrombosis and Haemostasis 1, 1935-1944.
    [ ABSTRACT ] [ FULL TEXT ]
  61. David, D., Santos, I. M. A., Johnson, K., Tuddenham, E. G. D., McVey, J. H. (2003). Analysis of the consequences of premature termination codons within factor VIII coding sequences. Journal of Thrombosis and Haemostasis 1, 139-146.
    [ ABSTRACT ] [ FULL TEXT ]
  62. Davidson, C. J., Hirt, R. P., Lal, K., Snell, P., Elgar, G., Tuddenham, E. G. D., McVey, J. H. (2003). Molecular evolution of the vertebrate blood coagulation network. Thrombosis and Haemostasis 89, 420-428.
    [ ABSTRACT ]
  63. Davidson, C. J., Tuddenahm, E. G., McVey, J. H. (2003). 450 million years of hemostasis. Journal of Thrombosis and Haemostasis 1, 1487-1494.
    [ ABSTRACT ] [ FULL TEXT ]
  64. McVey, J. (2003). Your bleeding heart: lessons from low tissue factor expression in mice. Trends in Pharmacological Science 24, 269-272.
    [ ABSTRACT ]
  65. Mumford, A. D., McVey, J. H., Morse, C. V., Gomez, K., Steen, M., Norstrom, E. A., Tuddenham, E. G. D., Dahlrack, B., Bolton-Maggs, P. H. B. (2003). Factor V 1359T: a novel mutation associated with thrombosis and resistance to activated protein C. British Journal of Haematology 123, 496-501.
    [ ABSTRACT ]
  66. Zhang, B., Cunningham, M. A., Nichols, W. C., Bernat, J. A., Seligsohn, U., Pipe, S. W., McVey, J. H., Schulte-Overberg, U., de Bosch, N. B., Ruiz-Saez, A., White, G. C., Tuddenham, E. G. D., Kaufman, R. J., Ginsburg, D. (2003). Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nature Genetics 34, 220-225.
    [ ABSTRACT ]
  67. Mumford, A. D., Laffan, M., O'Donnell, J., McVey, J. H., Johnson, D. J. D., Manning, R. A., Kemball-Cook, G. (2002). A Tyr346 → Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy. British Journal of Haematology 118, 589-594.
    [ ABSTRACT ] [ FULL TEXT ]
  68. Brown, P. J., Gill, A. C., Nugent, P. G., McVey, J. H., Tomley, F. M. (2001). Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily. FEBS Letters 497, 31-38.
    [ ABSTRACT ] [ FULL TEXT ]
  69. Chen, D., Riesbeck, K., McVey, J. H., Kemball-Cook, G., Tuddenham, E. G. D., Lechler, R. I., Dorling, A. (2001). Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins. Xenostransplantation 8, 258-265.
    [ ABSTRACT ]
  70. Christian, M., Marangos, P., Mak, I., McVey, J., Barker, F., White, J., Brosens, J. J. (2001). Interferon-γ modulates prolactin and tissue factor expression in differentiating human endometrial stromal cells. Endocrinology 142, 3142-3151.
    [ ABSTRACT ] [ FULL TEXT ]
  71. David, D., Saenko, E. L., Santos, I. M. A., Johnson, D. J. D., Tuddenham, E. G. D., McVey, J. H., Kemball-Cook, G. (2001). Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM–) and G1948D (CRMr). British Journal of Haematology 113, 604-615.
    [ ABSTRACT ]
  72. McVey, J. H., Boswell, E., Mumford, A. D., Kemball-Cook, G., Tuddenham, E. G. D. (2001). Factor VII deficiency and the FVII mutation database. Human Mutation 17, 3-17.
    [ ABSTRACT ]
  73. Dorling, A., Chen, D., Riesbeck, K., McVey, J., Kemball-Cook, G., Tuddenham, E. G., Lechler, R. I. (2000). Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis. Transplantation Proceedings 32, 971.
  74. Millar, D. S., Kemball-Cook, G., McVey, J. H., Tuddenham, E. G., Mumford, A. D., Attock, G. B., Reverter, J. C., Lanir, N., Parapia, L. A., Reynaud, J., Meili, E., von Felton, A., Martinowitz, U., Prangnell, D. R., Krawczak, M., Cooper, D. N. (2000). Molecular analysis of the genotype-phenotype relationship in factor VII deficiency. Human Genetics 107, 327-342.
    [ ABSTRACT ]
  75. Shibata, M., Shima, M., Morichika, S., McVey, J., Tuddenham, E. G. D., Tanaka, I., Suzuki, H., Nogami, K., Minamoto, Y., Hato, T., Saenko, E. L., Scandella, D., Yoshioka, A. (2000). An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia A due to deletion of a large portion of the A1 domain DNA sequence. Thrombosis and Haemostasis 84, 442-448.
    [ ABSTRACT ]
  76. Ventura, C., Santos, A. I. M., Tavares, A., Gago, T., Lavinha, J., McVey, J. H., David, D. (2000). Molecular genetic analysis of factor XI deficiency: identification of five novel gene alterations and the origin of type II mutation in Portuguese families. Thrombosis and Haemostasis 84, 833-840.
    [ ABSTRACT ]
  77. Chen, D., Riesbeck, K., Kemball-Cook, G., McVey, J. H., Tuddenham, E. G. D., Lechler, R. I., Dorling, A. (1999). Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins. Transplantation 67, 467-474.
    [ ABSTRACT ]
  78. Chen, D., Riesbeck, K., McVey, J. H., Kemball-Cook, G., Tuddenham, E. G. D., Lechler, R. I., Dorling, A. (1999). Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins. Transplantation 68, 832-839.
    [ ABSTRACT ]
  79. Houston, P., Dickson, M. C., Ludbrook, V., White, B. Schwachtgen, J.-L., McVey, J. H., Mackman, N., Reese, J. M., Gorman, D. G., Campbell, C., Braddock, M. (1999). Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1. Arteriosclerosis, Thrombosis, and Vascular Biology 19, 281-289.
    [ ABSTRACT ] [ FULL TEXT ]
  80. McVey, J. H. (1999). Tissue factor pathway. Bailleres Best Practice & Research in Clinical Haematology 12, 361-372.
    [ ABSTRACT ]
  81. Neerman-Arbez, M., Johnson, K. M., Morris, M. A., McVey, J. H., Peyvandi, F., Nichols, W. C., Ginsburg, D., Rossier, C., Antonarakis, S. E., Tuddenham, E. G. D. (1999). Molecular analysis of the ERGIC-53 gene in 35 families with combined factor V-factor deficiency. Blood 93, 2253-2260.
    [ ABSTRACT ] [ FULL TEXT ]
  82. Kemball-Cook, G., Johnson, D. J. D., Takamiya, O., Banner, D. W., McVey, J. H., Tuddenham, E. G. D. (1998). Coagulation factor VII Gln100 → Arg. Amino acid substitution at the epidermal grow.th factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function. The Journal of Biological Chemistry 273, 8516-8521.
    [ ABSTRACT ] [ FULL TEXT ]
  83. Mansvelt, E. P. G., Laffan, M., McVey, J. H., Tuddenham, E. G. D. (1998). Analysis of the F8 gene in individuals with high plasma factor VIII:C levels and associated venous thrombosis. Thrombosis and Haemostasis 80, 561-565.
    [ ABSTRACT ]
  84. McVey, J. H., Boswell, E. J., Takamiya, O., Tamagnini, G., Valente, V., Fidalgo, T., Layton, M., Tuddenham, E. G. D. (1998). Exclusion of the first EGF domain of factor VII by a splice site mutation causes lethal factor VII deficiency. Blood 92, 920-926.
    [ ABSTRACT ] [ FULL TEXT ]
  85. Palmer, D. B., McVey, J. H., Purohit, R., Picard, J., Dyson, P. J. (1998). Characterization of a recent retroposon insertion on mouse Chromosome 2 and localization of the cognate parental gene to Chromosome 11. Mammalian Genome 9, 103-106.
    [ ABSTRACT ]
  86. Riesbeck, K., Chen, D., Kemball-Cook, G., McVey, J. H., George, A. J. T., Tuddenham, E. G. D., Dorling, A., Lechler, R. I. (1998). Expression of hirudin fusion proteins in mamalian cells: a strategy for prevention of intravascular thrombosis. Circulation 98, 2744-2752.
    [ ABSTRACT ] [ FULL TEXT ]
  87. Tuddenham, E. G. D., McVey, J. H. (1998). The genetic basis of inhibitor development in haemophilia A. Haemophilia 4, 543-545.
    [ ABSTRACT ]
  88. Morichika, S., Shima, M., Kamisue, S., Tanaka, I., Imanaka, Y., Suzuki, H., Shibata, H., Pemberton, S., Gale, K., McVey, J., Tuddenham, E. G. D., Yoshioka, A. (1997). Factor VIII gene analysis in Japanese CRM-positive and CRM-reduced haemophilia A patients by single-strand conformation polymorphism. British Journal of Haematology 98, 901-906.
    [ ABSTRACT ]
  89. Riesbeck, K., Dorling, A., Kemball-Cook, G., McVey, J. H., Jones, M., Tuddenham, E. G., Lechler, R. I. (1997). Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface. Thrombosis and Haemostasis 78, 1488-1494.
    [ ABSTRACT ]
  90. Imanaka, Y., Lal, K., Nishimura, T., Bolton-Maggs, P. H. B., Tuddenham, E. G. D., McVey, J. H. (1995). Identification of two novel mutations in non-Jewish factor XI deficiency. British Journal of Haematology 90, 916-920.
    [ ABSTRACT ] [ FULL TEXT ]
  91. Pugh, R. E., McVey, J. H., Tuddenham, E. G., Hancock, J. F. (1995). Six point mutations that cause factor XI deficiency. Blood 85, 15009-1516.
    [ ABSTRACT ] [ FULL TEXT ]
  92. Takamiya, O. T., Abe, S., Yoshioka, A., Nakajima, K., McVey, J. H., Tuddenham, E. G. D. (1995). FactorVIIShinjo: a dysfunctional factor VII variant homozygous for the substitution Gln for Arg at position 79. Haemostasis 25, 89-97.
    [ ABSTRACT ]
  93. Kemball-Cook, G., Garner, I., Imanaka, Y., Nishimura, T., O'Brien, D. P., Tuddenham, E. G. D., McVey, J. H. (1994). High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector. Gene 139, 275-279.
    [ ABSTRACT ]
  94. Kochhan, L., Lalloz, M. R., Oldenburg, J., McVey, J. H., Olek, K., Brackmann, H. H., Tuddenham, E. G. D., Schwaab, R. (1994). Haemophilia A diagnosis by automated fluorescent DNA detection of ten factor VIII intron 13 dinucleotide repeat alleles. Blood Coagulation & Fibrinolysis 5, 497-501.
    [ ABSTRACT ]
  95. Lalloz, M. R. A., Schwaab, R., McVey, J. H., Michaelides, K., Tuddenham, E. G. D.(1994). Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene. British Journal of Haematology 86, 804-8009.
    [ ABSTRACT ] [ FULL TEXT ]
  96. McVey, J. H. (1994). 3 Tissue factor pathway. Baillière's Clinical Haematology 7, 469-484.
    [ ABSTRACT ]
  97. McVey, J. H. (1994). Staden Plus. Methods in Molecular Biology 25, 171-179.
  98. Nathwani, A. C., Gale, K. M., Pemberton, K. D., Crossman, D. C., Tuddenham, E. G. D., McVey, J. H. (1994). Efficient gene transfer into human umbilical vein endothelial cells allows functional analysis of the human tissue factor gene promoter. Bristish Journal of Haematology 88, 122-128.
    [ ABSTRACT ] [ FULL TEXT ]
  99. O'Brien, D. P., Kemball-Cook, G., Hutchinson, A. M., Martin, D. M. A., Johnson, D. J. D., Byfield, P. G. H., Takamiya, O., Tuddenham, E. G. D., McVey, J. H. (1994). Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule (FVII-R79Q). Biochemistry 33, 14162-14169.
    [ ABSTRACT ]
  100. Connolly, D. J., Cotterill, L. A., Hederer, R. A., Thorpe, C. J., Travers, P. J., McVey, J. H., Dyson, J., Robinson, P. J. (1993). A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site. The Journal of Immunology 151, 6089-60098.
    [ ABSTRACT ]
  101. McVey, J. H., Michaelides, K., Hansen, L. P., Ferguson-Smith, M., Tilghman, S., Krumlauf, R., Tuddenham, E. G. D. (1993). A G → A substitution in an HNF I binding site in the human α-fetoprotein gene is associated with hereditary persistence of α-fetoprotein (HPAFP). Human Molecular Genetics 2, 379-384.
    [ ABSTRACT ]
  102. Takamiya, O., Kemball-Cook, G., Martin, D. M. A., Cooper, D. N., von Felten, A., Meili, E., Hann, I., Prangnell, D. R., Lumley, H., Tuddenham, E. G. D., McVey, J. H. (1993). Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII. Human Molecular Genetics 2, 1355-1359.
    [ ABSTRACT ]
  103. Palmer, D. B., McVey, J. H., Robinson, P. J., Dyson, P. J. (1992). The chromatin structure of the mouse beta-2-microglobulin locus. Differentiation 51, 201-207.
    [ ABSTRACT ]
  104. Lalloz, M. R. A., McVey, J. H., Pattinson, J. K., Tuddenham, E. G. D. (1991). Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene. The Lancet 338, 207-211.
    [ ABSTRACT ]
  105. O'Brien, D. P., Gale, K. M. anderson, J. S., McVey, J. H., Miller, G. J., Meade, T. W., Tuddenham, E. G. D. (1991). Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male. Blood 78, 132-140.
    [ ABSTRACT ] [ FULL TEXT ]
  106. Schwaab, R., Ludwig, M., Kochhan, L., Oldenburg, J., McVey, J. H., Egli, H., Brackmann, H. H., Olek, K. (1991). Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain. Thrombosis Research 61, 225-234.
    [ ABSTRACT ]
  107. Crossman, D. C., Carr, D. P., Tuddenham, E. G., Pearson, J. D., McVey, J. H. (1990). The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester. The Journal of Biological Chemistry 265, 9782-9787.
    [ ABSTRACT ] [ FULL TEXT ]
  108. Owen, F., Poulter, M., Shah, T., Collinge, J., Lofthouse, R., Baker, H., Ridley, R., McVey, J., Crow, T. J. (1990). An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease. Molecular Brain Research 7, 273-276.
    [ ABSTRACT ]
  109. Paleolog, E. M., Crossman, D. C., McVey, J. H., Pearson, J. D. (1990). Differential regulation by cytokines of constitutive and stimulated secretion of von Willebrand factor from endothelial cells. Blood 75, 688-695.
    [ ABSTRACT ] [ FULL TEXT ]
  110. Pattinson, J. K., Millar, D. S., McVey, J. H., Grundy, C. B., Wieland, K., Mibashan, R. S., Martinowitz, U., Tan-Un, K., Vidaud, M., Goossens, M., Goossens, M. (1990). The molecular genetic analysis of hemophilia A: a directed search strategy for the detection of point mutations in the human factor VIII gene. Blood 76, 2242-2248.
    [ ABSTRACT ] [ FULL TEXT ]
  111. Pattinson, J. K., McVey, J. H., Boon, M., Ajani, A., Tuddenham, E. G. D. (1990). CRM+ haemophilia A due to a missense mutation (372→Cys) at the internal heavy chain thrombin cleavage site. British Journal of Haematology 75, 73-77.
    [ ABSTRACT ] [ FULL TEXT ]
  112. Nomura, S., Hashmi, S., McVey, J. H., Ham, J., Parker, M., Hogan, B. L. N. (1989). Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse Sparc (osteonectin) gene. The Journal of Biological Chemistry 264, 12201-12207.
    [ ABSTRACT ] [ FULL TEXT ]
  113. Graham, A., Papalopulu, N., Lorimer, J., McVey, J. H., Tuddenham, E. G. D., Krumlauf, R. (1988). Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Genes & Development 2, 1424-1438.
    [ ABSTRACT ] [ FULL TEXT ]
  114. McVey, J. H., Nomura, S., Kelly, P., Mason, I. J., Hogan, B. L. M. (1988). Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region. The Journal of Biological Chemistry 263, 11111-11116.
    [ ABSTRACT ] [ FULL TEXT ]
  115. Barlow, D. P., McVey, J. H., Hogan, B. L. M. (1987). [26] Molecular cloning of laminin. Methods in Enzymology 144, 464-474.
  116. Holland, P. W. H., Harper, S. J., McVey, J. H., Hogan, B. L. M. (1987). In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. The Journal of Cell Biology 105, 473-482.
    [ ABSTRACT ] [ FULL TEXT ]
  117. Krumlauf, R., Holland, P. W. H., McVey, J. H., Hogan, B. L. M. (1987). Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2. 1. Development 99, 603-617.
    [ ABSTRACT ] [ FULL TEXT ]
  118. Craig, R. K., Edbrooke, M. R., Riley, J. H., McVey, J. H., Parker, D. (1985). Differential expression of the human calcitonin--CGRP gene in medullary thyroid carcinoma and lung carcinoma cell lines. Recent Results Cancer Research 99, 71-78.
  119. Edbrooke, M. R., Parker, D., McVey, J. H., Riley, J. H., Sorenson, G. D., Pettengill, O. S., Craig, R. K. (1985). Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma. The EMBO Journal 4, 715-724.
    [ ABSTRACT ] [ FULL TEXT ]

Invited Book Chapters
  1. Gomez, K., Tuddenham, E. G. D., McVey, J. H. (2010). Normal haemostasis. In Postgraduate Haematology. ed. Hoffbrand, A. V., Catovsky, D., Tuddenham, E. G. D., Green, A. R., pp. 746-771. Chichester: John Wiley & Sons, Ltd.
  2. Kemball-Cook, G., McVey, J. H., Tuddenham, E. G. D. (2009). Structure, biology, and genetics of factor VIII. In Hematology: basic principles and practice, R. Hoffman, E. J. Benz, S. J. Shattil, B. Furie, L. Silberstein, P. McGlave, and H. Heslop eds. Churchill Livingstone.
  3. McVey, J. H. (2007). Molecular phylogeny. In Endothelial Biomedicine. ed. Aird, W. C., pp. 113-121. Cambridge: Cambridge University Press.
  4. McVey, J. H. (2007). Tissue factor and factor VII: initiation of blood coagulation. In Protein Epidemiology: Understanding Human Disease at the Level of Protein Structure and Function. ed. Dunn, B. Henry Stewart Talks.
    [ PRESENTATION ]
  5. McVey, J. H., Tuddenham, E. G. D. (2007). Genomics of Haemostasis. In Genomics and Clinical Medicine. ed. Kumar, D., Weatherall, D., Oxford: Oxford University Press.
  6. McVey, J. H. (2006). Coagulation Factors. In Clinical Hematology. ed. Young, N. S., Gerson, S. L., High, K. A., pp. 103-112. Philadelphia: Elsevier.
  7. Kemball-Cook, G., Tuddenham, E. G. D., McVey J. H. (2005). Normal haemostasis. In Postgraduate Haematology. ed. Hoffbrand, E. V., Tuddenham, E. G. D., Catovsky, D., pp. 783-807. Oxford: Blackwell Publishing Ltd.
  8. McVey, J. H., Tuddenham, E. G. D. (2003). Hemophilia and other bleeding disorders: genetics. In Encyclopedia of the Human Genome. ed. Cooper, D. New York: Nature Publishing Group.
  9. Johnson, K. M., McVey, J. H. (1999). Molecular analysis in factor XI deficiency. In Methods in Molecular Medicine 31: Haemostasis and Thrombosis Protocols. ed. Perry, D. J., Passi, K. J., pp. 211-221. Totowa: Humana Press Inc.
  10. O'Brien, D. P., McVey, J. H. (1993). Blood coagulation, inflammation, and defence. In The Natural Immune System: Humoral Factors. ed. Sim, E., Kerr, M. A. Oxford: Oxford University Press.
  11. McVey, J. H., Pattinson, J. K., Tuddenham, E. G. D. (1990). Molecular biology in blood coagulation. In Recent Advances in Blood Coagulation. Poller, L. ed., pp. 79-92. Edinburgh: Churchill Livingstone.
  12. Papalopulu, N., Graham, A., Lorimer, J., Kenny, R., McVey, J., Krumlauf, R. (1987). Structure, expression and evolutionary relationships of murine homeobox genes in the HOX-2 cluster. In Cell to Cell Signals in Mammalian Development. ed. Mummery, C. L. Berlin: Springer-Verlag.
  13. Hogan, B. L., Barlow, D. P., Green, N. M., Elliott, R. W., McVey, J., Patel, G., Kurkinen, M., Cooper, A. R. (1985). Laminin: towards the structure of the protein and its genes. In The Proceedings of the International Symposium on Biology and Chemistry of Basement Membranes, Mishima, Japan, 24-26th June 1985. pp. 147-154. Amsterdam: Elsevier.
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